Download PDF by Michael W. Thompson, Louis B. Hersh (auth.), Nigel M.: Aminopeptidases in Biology and Disease

By Michael W. Thompson, Louis B. Hersh (auth.), Nigel M. Hooper, Uwe Lendeckel (eds.)

ISBN-10: 1441988696

ISBN-13: 9781441988690

ISBN-10: 1461346983

ISBN-13: 9781461346982

Aminopeptidases in Biology and Disease offers a entire assessment of the rising function of aminopeptidases in various organic strategies and disorder events. procedures as assorted as angiogenesis, antigen presentation, neuropeptide and hormone processing, being pregnant and copy, protein turnover, reminiscence, irritation, tumour development, melanoma and metastasis, blood strain and high blood pressure all significantly contain a number of aminopeptidases. the person chapters were written by way of specialists within the box who've supplied certain debts of the principal roles performed by way of numerous aminopeptidases in biology and disease.

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Extra resources for Aminopeptidases in Biology and Disease

Example text

1990) and purified MetAP2 from pig (Kendall and Bradshaw 1992), Saccharomyces cerevisiae (Li and Chang 1995), and human (Li and Chang 1996) against short peptide substrates in vitro confirmed this specificity. Although the second residue primarily determines if Metinit hydrolysis occurs, differences between the activities of MetAP1 and MetAP2 against the same protein substrate have been observed in vivo (Chen et al. 2002; Towbin et al. 2003; Turk et al. 1999). There are currently at least two possible reasons for differences in MetAP1 and MetAP2 activities in vivo.

2000, Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class I. Eur. J. lmmunol. 30: 1496-1506. B. , 2003, Proteolytic cleavage ofthe puromycin-sensitive aminopeptidase generates a substrate binding doma in. Arch. Biochem. Biophys. 415: 80-86. F. , 1986, Inactivation and metabolism ofneuropeptides. Ann. Rev. Neurosci. 9: 415-434. , 1988, Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopept idases.

51: 1552-1559. , 1994, Increased fearfulness ofFyn tyrosine kinase deficient mice. Brain Res. Mol. Brain Res. 27: 179-182. , 1994, Internalization and nuclear localization of peptide hormones. Biochem. Pharmacol. 47: 63-76. , 1994, Effect of ubenimex on the proliferation and differentiation ofU937 human histiocytic lymphoma cells. Leukemia 8: 2188-2193. , 2001a, Puromycin-sensitive aminopeptidase is essential for the maternal recognition of pregnancy in mice. Mol. Endocrinol. 15: 882-893 . , 2001b, Male reproductive defects caused by puromycin-sensitive amionpeptidase deficiency in mice.

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Aminopeptidases in Biology and Disease by Michael W. Thompson, Louis B. Hersh (auth.), Nigel M. Hooper, Uwe Lendeckel (eds.)


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