Download e-book for kindle: Advances in Immunology, Vol. 16 by F.J. Dixon, Henry G. Kunkel (Eds.)

By F.J. Dixon, Henry G. Kunkel (Eds.)

ISBN-10: 012022416X

ISBN-13: 9780120224166

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Additional resources for Advances in Immunology, Vol. 16

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Family which illustrates inheritance of a rare gene complex with deletion of the IgG3 cistron on one chromosome. This chromosome is indicated by an arrow and the gene complexes are drawn on the basis of the known phenotypes of the respective individuals. Heavy lines-paternal chromosomes; double lines-maternal chromosomes. The pedigree represents a family with a sister and brother with a rare Gm"+, -, Gm' gene complex. Two of the brother's children and three of the sister's children appeared to have the same rare gene complex.

4 and 5 ) can be obtained. i .. ;i . I . 0 .. ~ t Pspltdw h 40 00 100 120 140 . , ~ (d) 160 friclion nunbml FIG 3. Profiles of the fractionation on Sephadex G-150 of various XgC subclass proteins after mild pepsin digestion which gives rise to pFc’ fragments. ( a ) 24 hours peptic digest of IgG1; ( I ) ) 6 hours peptic digest of IgC2; ( c ) 1 hour peptic digest of IgG3; ( d ) 2 hours peptic digest of IgC4. The pFc’ fragment is eluted in the same position from all the four subclasses. ) 17 HUMAN IMMUNOGLOBULINS FIG.

They have probably evolved through rare inter- or intra-cistronic recombinations. M = Mongoloid; C = Caucasian. Parentheses indicate unusual marker. IUNOGLOBULINS C. BIOLOGICAL ACTIVITIES The main biological activity of imiiiunoglobuliiis is their antigen binding which resides in the Fab fragment and is specified by the V regions. However, increasing attention has been focused on other biological activities which mainly involve the Fc part of the heavy chains, such as C l q fixation, transplacental transfer, PCA reactivity, binding to receptors on macrophages and lymphocytes, binding with rheumatoid factors, and interaction with staphylococcal A protein.

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Advances in Immunology, Vol. 16 by F.J. Dixon, Henry G. Kunkel (Eds.)

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