Gülsen Ökten (auth.), Kursad Turksen (eds.)'s Adult and Embryonic Stem Cells PDF

By Gülsen Ökten (auth.), Kursad Turksen (eds.)

ISBN-10: 1617796298

ISBN-13: 9781617796296

This quantity will conceal a sequence of experiences on stem cells together with grownup and embryonic stem cells. audio system have been invited to provide those talks in the course of the Stem telephone Symposia in fall of 2010, in Samsun, Turkey. specific point of this quantity is that it brings a multidisciplinary element of stem cells extracted from a symposium.

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Thus, in neonatal and adult bone preparations, MSCs were found within the PDGFRa + population, but most of them derived from a nonneural/NC pathway. Together, these results suggest that MSCs arise in multiple waves of distinct origins: The first MSCs in the embryo, which are identifiable by the method described by Takashima et al. (2007), are derived from neuroepithelium/NC. Later, this early, but transient, population is eventually replaced by MSCs derived from an as-yet-unidentified pathway. An important question raised by this study is what is the other source of MSCs?

Given that both cell types successfully displayed many features of MSCs in other tissues, not only pericytes but also nonpericytic cells can behave as multipotent progenitors that could be recruited from tissues showing fetal mesenchyme-derived connective tissue. In other words, as suggested by Caplan (2008), all pericytes are not MSCs. Undoubtedly, a portion of the pericyte population would be highly differentiated cells to execute the given tasks as mentioned above. Taken together, it is possible to conclude that cells of the 2 Searching for In Vivo Traces of Mesenchymal Stem Cells and Their Ancestors 19 Fig.

Over the last decade, various mature cell types, some of which are functional, have been shown to be derived in vitro from ESCs in mice and human (reviewed in Billon et al. [2008]). Retinoid acid for osteoblast and chondrocyte differentiation (Kawaguchi et al. 2005) and transforming growth factor-b (TGFb) for myogenic differentiation (Mahmood et al. 2010) were reported to be the key factors for quantitative induction of mesenchymal derivatives. One of the first attempts on human ESCs (hESCs) was reported by Barberi et al.

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Adult and Embryonic Stem Cells by Gülsen Ökten (auth.), Kursad Turksen (eds.)

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